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1

1,7- and 2,7-naphthyridine derivatives as potent and highly specific PDE5 inhibitors

Tatsuzo Ukita, Yoshinori Nakamura, Akira Kubo, Yasuo Yamamoto, Yasunori Moritani, Kunio Saruta, Takanori Higashijima, Jun Kotera, Kotomi Fujishige, Michino Takagi, Kohei Kikkawa, Kenji Omori

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 239 KB

english, 2003

2

Asymmetric Conjugate Reduction of α,β-Unsaturated Esters Using a Chiral Phosphine−Copper Catalyst

Appella, Daniel H., Moritani, Yasunori, Shintani, Ryo, Ferreira, Eric M., Buchwald, Stephen L.

Journal:

Journal of the American Chemical Society

Year:

1999

Language:

english

File:

PDF, 71 KB

english, 1999

3

Impact of prolonged neuromuscular electrical stimulation on metabolic profile and cognition-related blood parameters in type 2 diabetes: A randomized controlled cross-over trial

Miyamoto, Toshiaki, Iwakura, Toshio, Matsuoka, Naoki, Iwamoto, Masako, Takenaka, Mariko, Akamatsu, Yasunori, Moritani, Toshio

Journal:

Diabetes Research and Clinical Practice

Year:

2018

Language:

english

File:

PDF, 460 KB

english, 2018

4

ChemInform Abstract: Asymmetric Conjugate Reduction of α,β-Unsaturated Esters Using a Chiral Phosphine—Copper Catalyst.

Daniel H. Appella, Yasunori Moritani, Ryo Shintani, Eric M. Ferreira, Stephen L. Buchwald

Journal:

Year:

2000

File:

PDF, 31 KB

2000

5

ChemInform Abstract: An Efficient Synthesis of the Antiasthmatic Agent T-440: A Selective N-Alkylation of 2-Pyridone.

Masakatsu Sugahara, Yasunori Moritani, Tooru Kuroda, Kazuhiko Kondo, Hideshi Shimadzu, Tatsuzo Ukita

Journal:

Year:

2000

File:

PDF, 31 KB

2000

6

ChemInform Abstract: Synthesis of β-Alkyl Cyclopentanones in High Enantiomeric Excess via Copper-Catalyzed Asymmetric Conjugate Reduction.

Yasunori Moritani, Daniel H. Appella, Valdas Jurkauskas, Stephen L. Buchwald

Journal:

Year:

2000

File:

PDF, 35 KB

2000

7

ChemInform Abstract: Synthetic and Mechanistic Study of the Acid-Promoted Aromatization of the Diels—Alder Adduct: 6,7-Dimethoxy-1- (4-pyridyl)-1,4-epoxytetrahydronaphthalene-2,3-dicarboxylate.

Masakatsu Sugahara, Yasunori Moritani, Tooru Kuroda, Kazuhiko Kondo, Tatsuzo Ukita

Journal:

Year:

2002

File:

PDF, 35 KB

2002

8

ChemInform Abstract: Synthesis and Evaluation of Pyrrolin-2-one Compounds, a Series of Plasminogen Activator Inhibitor-1 Inhibitors.

Hiroshi Miyazaki, Tsuyoshi Ogiku, Hiroshi Sai, Yasunori Moritani, Akio Ohtani, Hiroshi Ohmizu

Journal:

Year:

2010

File:

PDF, 34 KB

2010

9

A novel asymmetric synthesis of axial-equatorial furofuran lignans: A synthesis of (+)-fargesin

Shin-ichi Yoshida, Takeshi Yamanaka, Tutomu Miyake, Yasunori Moritani, Hiroshi Ohmizu, Tameo Iwasaki

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 210 KB

english, 1995

10

Asymmetric syntheses of lignans utilizing novel diastereoselective Michael addition of cyanohydrin: Syntheses of (+)-fargesin and (−)-picropodophyllone

Shin-ichi Yoshida, Takeshi Yamanaka, Tutomu Miyake, Yasunori Moritani, Hiroshi Ohmizu, Tameo Iwasaki

Journal:

Year:

1997

Language:

english

File:

PDF, 686 KB

english, 1997

11

An efficient synthesis of highly functionalized unsymmetrical biphenyls having substituents on the ortho positions

Masami Takahashi, Yasunori Moritani, Tsuyoshi Ogiku, Hiroshi Ohmizu, Kazuhiko Kondo, Tameo Iwasaki

Journal:

Tetrahedron Letters

Year:

1992

Language:

english

File:

PDF, 153 KB

english, 1992

12

A highly stereoselective synthesis of α-substituted cis-α, β-dibenzyl-γ-butyrolactones

Yasunori Moritani, Chiaki Fukushima, Tsuyoshi Ogiku, Tatsuzo Ukita, Toshikazu Miyagishima, Tameo Iwasaki

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 259 KB

english, 1993

13

A synthesis of α-substituted trans-α, β-dibenzyl-γ-butyrolactones: diastereofacial differentiation in the electrophilic attack on the metal enolates of α, β-dibenzyl-γ-butyrolactones

Moritani Yasunori, Ukita Tatsuzo, Nishitani Takashi, Seki Masahiko, Iwasaki Tameo

Journal:

Tetrahedron Letters

Year:

1990

Language:

english

File:

PDF, 261 KB

english, 1990

14

Asymmetric induction by sulfinyl chirality. A total synthesis of (+)-talaromycin A and (−)-talaromycin B

Chuzo Iwata, Masahiro Fujita, Yasunori Moritani, Kohji Hattori, Takeshi Imanishi

Journal:

Tetrahedron Letters

Year:

1987

Language:

english

File:

PDF, 262 KB

english, 1987

15

A synthesis of 1-pyridylnaphthalene lignan analogs

Masakatsu Sugahara, Yasunori Moritani, Yoshihiro Terakawa, Tsuyoshi Ogiku, Tatsuzo Ukita, Tameo Iwasaki

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 283 KB

english, 1998

16

Stereoselective synthesis of all isomers of 2-methyl-1,6-diaxaspiro[4.5]decane (insect pheromone) using a chiral sulfoxide auxiliary

Chuzo Iwata, Yasunori Moritani, Kenji Sugiyama, Masahiro Fujita, Takeshi Imanishi

Journal:

Tetrahedron Letters

Year:

1987

Language:

english

File:

PDF, 277 KB

english, 1987

17

Asymmetric functionalization at a prochiral carbon center by the aid of sulfinyl chirality: A selective formation of 6-substituted (3R,SS)- and (3S,SS)-3-hydroxymethyl-3,4-dihydro-5-(p-tolyl)sulfinyl-2H-pyrans

Chuzo Iwata, Masahiro Fujita, Yasunori Moritani, Kenji Sugiyama, Kohji Hattori, Takeshi Imanishi

Journal:

Tetrahedron Letters

Year:

1987

Language:

english

File:

PDF, 245 KB

english, 1987

18

Effect of Aldehyde Dehydrogenase-2 Genotype on Cardiac Autonomic Nervous Responses to Moderate Alcohol Ingestion

Yasunori Akamatsu, Tatsuya Hayashi, Naoki Sakane, Toshio Moritani

Journal:

Alcoholism: Clinical and Experimental Research

Year:

2008

Language:

english

File:

PDF, 235 KB

english, 2008

19

Novel Selective PDE IV Inhibitors as Antiasthmatic Agents. Synthesis and Biological Activities of a Series of 1-Aryl-2,3-bis(hydroxymethyl)naphthalene Lignans

Iwasaki, Tameo, Kondo, Kazuhiko, Kuroda, Tooru, Moritani, Yasunori, Yamagata, Shinsuke, Sugiura, Masaki, Kikkawa, Hideo, Kaminuma, Osamu, Ikezawa, Katsuo

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 406 KB

english, 1996

20

Novel, Potent, and Selective Phosphodiesterase 5 Inhibitors: Synthesis and Biological Activities of a Series of 4-Aryl-1-isoquinolinone Derivatives

Ukita, Tatsuzo, Nakamura, Yoshinori, Kubo, Akira, Yamamoto, Yasuo, Moritani, Yasunori, Saruta, Kunio, Higashijima, Takanori, Kotera, Jun, Takagi, Michino, Kikkawa, Kohei, Omori, Kenji

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 316 KB

english, 2001

21

Synthesis of β-Alkyl Cyclopentanones in High Enantiomeric Excess via Copper-Catalyzed Asymmetric Conjugate Reduction

Moritani, Yasunori, Appella, Daniel H., Jurkauskas, Valdas, Buchwald, Stephen L.

Journal:

Journal of the American Chemical Society

Year:

2000

Language:

english

File:

PDF, 93 KB

english, 2000

22

A highly stereoselective synthesis of 3-hydroxy-1-aryltetralin lignans based on the stereoselective hydroxylation of ?,?-dibenzyl-?-butyro-lactones: the first synthesis of (�)-cycloolivil

Moritani, Yasunori, Ukita, Tatsuzo, Hiramatsu, Hajime, Okamura, Kimio, Ohmizu, Hiroshi, Iwasaki, Tameo

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1996

Language:

english

File:

PDF, 1.02 MB

english, 1996

23

The first synthesis of (�)-cycloolivil: a highly stereoselective synthesis of 3-hydroxy-1-aryltetralin lignans based on the stereoselective hydroxylation of ?,?-dibenzyl-?-butyrolactones

Moritani, Yasunori, Ukita, Tatsuzo, Ohmizu, Hiroshi, Iwasaki, Tameo

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1995

Language:

english

File:

PDF, 223 KB

english, 1995

24

Scalable Synthesis of a Nonracemic α-Arylpropionic Acid via Ketene Desymmetrization for a Glucokinase Activator

Yamagami, Takafumi, Moriyama, Noriaki, Kyuhara, Masahiro, Moroda, Atsushi, Uemura, Takeshi, Matsumae, Hiroaki, Moritani, Yasunori, Inoue, Isao

Journal:

Organic Process Research & Development

Year:

2014

Language:

english

File:

PDF, 1.17 MB

english, 2014

25

Highly Diastereoselective Esterification of Ketenes Generated In Situ from Acyl Chlorides with ( R )-Pantolactone Derivatives

Yamagami, Takafumi, Hatsuda, Masanori, Utsugi, Masayuki, Kobayashi, Ryo, Moritani, Yasunori

Journal:

European Journal of Organic Chemistry

Year:

2013

Language:

english

File:

PDF, 449 KB

english, 2013

26

Stereoselective Syntheses of Cis - and Trans -Isomers of α-Hydroxy-α,β-dibenzyl-γ-butyrolactone Lignans: New Syntheses of (±)-Trachelogenin and (±)-Guayadequiol

Moritani, Yasunori, Fukushima, Chiaki, Ukita, Tatsuzo, Miyagishima, Toshikazu, Ohmizu, Hiroshi, Iwasaki, Tameo

Journal:

Journal of Organic Chemistry

Year:

1996

Language:

english

File:

PDF, 397 KB

english, 1996

27

Synthetic and mechanistic study of the acid-promoted aromatisation of the Diels–Alder adduct: 6,7-dimethoxy-1-(4-pyridyl)-1,4-epoxytetrahydronaphthalene-2,3-dicarboxylate

Sugahara, Masakatsu, Moritani, Yasunori, Kuroda, Tooru, Kondo, Kazuhiko, Ukita, Tatsuzo

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

2002

Language:

english

File:

PDF, 228 KB

english, 2002

28

Classification of AIDS-related lymphoma cases between 1987 and 2012 in Japan based on the WHO classification of lymphomas, fourth edition

Ota, Yasunori, Hishima, Tsunekazu, Mochizuki, Makoto, Kodama, Yoshinori, Moritani, Suzuko, Oyaizu, Naoki, Mine, Sohtaro, Ajisawa, Atsushi, Tanuma, Junko, Uehira, Tomoko, Hagiwara, Shotaro, Yajima, Kei

Journal:

Cancer Medicine

Year:

2014

Language:

english

File:

PDF, 1.17 MB

english, 2014

29

ChemInform Abstract: Highly Diastereoselective Esterification of Ketenes Generated in situ from Acyl Chlorides with (R)-Pantolactone Derivatives.

Yamagami, Takafumi, Hatsuda, Masanori, Utsugi, Masayuki, Kobayashi, Ryo, Moritani, Yasunori

Journal:

Year:

2014

File:

PDF, 36 KB

2014

30

Simple Synthesis of trans - α , β -Dibenzyl- γ -butyrolactone Lignans by Diastereoselective Reduction of α -Benzylidene- β -benzyl- γ -butyrolactones Using NaBH 4 –NiCl 2

Moritani, Yasunori, Fukushima, Chiaki, Miyagishima, Toshikazu, Ohmizu, Hiroshi, Iwasaki, Tameo

Journal:

Bulletin of the Chemical Society of Japan

Year:

1996

File:

PDF, 1.03 MB

1996

31

Synthetic studies on spiroketal natural products. III. Enantioselective synthesis of 1,6-dioxaspiro(4.5)decane compounds.

IWATA, CHUZO, MORITANI, YASUNORI, SUGIYAMA, KENJI, IZAKI, HITOSHI, KUROKI, TOSHIO, IMANISHI, TAKESHI

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1988

Language:

english

File:

PDF, 1.19 MB

english, 1988

32

Synthetic Studies on Spiroketal Natural Products. IV. A Stereoselective Synthesis of (3S,5S,6R,9R,Rs)-3-Benzyloxymethyl-9-hydroxymethyl-5-(p-tolyl)sulfinyl-1,7-dioxaspiro(5.5)undecane, a Key Intermediate for Talaromycins.

IWATA, Chuzo, MAEZAKI, Naoyoshi, HATTORI, Kohji, FUJITA, Masahiro, MORITANI, Yasunori, TAKEMOTO, Yoshiji, TANAKA, Tetsuaki, IMANISHI, Takeshi

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1993

File:

PDF, 1.07 MB

1993

33

An Efficient Synthesis of the Anti-asthmatic Agent T-440: A Selective N-Alkylation of 2-Pyridone.

SUGAHARA, Masakatsu, MORITANI, Yasunori, KURODA, Tooru, KONDO, Kazuhiko, SHIMADZU, Hideshi, UKITA, Tatsuzo

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

2000

File:

PDF, 564 KB

2000

34

Synthesis and Evaluation of Pyrrolin-2-one Compounds, a Series of Plasminogen Activator Inhibitor-1 Inhibitors

Miyazaki, Hiroshi, Ogiku, Tsuyoshi, Sai, Hiroshi, Moritani, Yasunori, Ohtani, Akio, Ohmizu, Hiroshi

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

2009

Language:

english

File:

PDF, 291 KB

english, 2009

35

Synthetic Studies on Spiroketal Natural Products. V. Total Synthesis of (+)-Talaromycin A and (-)-Talaromycin B.

IWATA, Chuzo, MAEZAKI, Naoyoshi, HATTORI, Kohji, FUJITA, Masahiro, MORITANI, Yasunori, TAKEMOTO, Yoshiji, TANAKA, Tetsuaki, IMANISHI, Takeshi

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1993

File:

PDF, 782 KB

1993

36

Cytotoxic Components of Bardanae Fructus (Goboshi).

MORITANI, Shuzo, NOMURA, Masaaki, TAKEDA, Yasunori, MIYAMOTO, Ken-ichi

Journal:

Biological & Pharmaceutical Bulletin

Year:

1996

File:

PDF, 532 KB

1996

37

Effect of Exericse and Nutrition upon Lifestyle-Related Disease and Cognitive Function

MORITANI, Toshio, AKAMATSU, Yasunori

Year:

2015

Language:

english

File:

PDF, 441 KB

english, 2015

38

Effect of Tryptophan, Vitamin B6, and Nicotinamide-Containing Supplement Loading between Meals on Mood and Autonomic Nervous System Activity in Young Adults with Subclinical Depression: A Randomized, Double-Blind, and Placebo-Controlled Study

TSUJITA, Natsuki, AKAMATSU, Yasunori, NISHIDA, Márcio Makoto, HAYASHI, Tatsuya, MORITANI, Toshio

Journal:

Journal of Nutritional Science and Vitaminology

Year:

2019

File:

PDF, 645 KB

2019

39

Physical Activity, Nutritional Status, and Autonomic Nervous System Activity in Healthy Young Adults with Higher Levels of Depressive Symptoms and Matched Controls without Depressive Symptoms: A Cross-Sectional Study

Tsujita, Natsuki, Akamatsu, Yasunori, Nishida, MÃ¡rcio Makoto, Hayashi, Tatsuya, Moritani, Toshio

Journal:

Year:

2020

File:

PDF, 497 KB

2020